Assay Detail
Binding
CHEMBL3853690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta-hexosaminidase alpha in human skin fibroblast lysate using 4-MU-N-acetyl-beta-D-glucosaminide-6-sulfate sodium salt as substrate assessed as 4-MU liberation by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-hexosaminidase subunit alpha (CHEMBL1250415) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp(2)-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.00 | 4.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3983808 | — | — | 1 | 4.00 |
| CHEMBL3982827 | — | — | 1 | 4.00 |
| CHEMBL3933402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3983808 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3982827 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3933402 | — | IC50 | = | 350000.0 | nM | - |