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Assay Detail

CHEMBL3854585

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Binding
Binding affinity to Pseudomonas aeruginosa HemO by intrinsic fluorescence quenching method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pseudomonas aeruginosa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Heme oxygenase (CHEMBL1075209)
Type SINGLE PROTEIN
Organism Pseudomonas aeruginosa

Publication

Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa.
Heinzl GA, Huang W, Yu W, Giardina BJ, Zhou Y, MacKerell AD, Wilks A, Xue F.
J Med Chem (2016) 59 : 6929 -6942
PubMed 27353344 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 25 5.04 5.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3955732 1 5.32
CHEMBL2346953 1 5.24
CHEMBL104315 1 5.21
CHEMBL3920262 1 5.17
CHEMBL3900440 1 5.17
CHEMBL54151 1 5.16
CHEMBL2346950 1 5.11
CHEMBL3932345 1 5.10
CHEMBL3928103 1 5.10
CHEMBL2346944 1 5.08
CHEMBL3982697 1 5.08
CHEMBL105167 1 5.06
CHEMBL105616 1 5.04
CHEMBL2346942 1 4.96
CHEMBL2346945 1 4.96
CHEMBL3960464 1 4.92
CHEMBL3969135 1 4.92
CHEMBL2346938 1 4.92
CHEMBL2346941 1 4.85
CHEMBL1976834 1 4.82
CHEMBL3944104 1 4.68
CHEMBL105099 1 -
CHEMBL3975335 1 -
CHEMBL2346937 1 -
CHEMBL3889940 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3955732 Kd = 4800.0 nM 5.32
CHEMBL2346953 Kd = 5700.0 nM 5.24
CHEMBL104315 Kd = 6200.0 nM 5.21
CHEMBL3920262 Kd = 6700.0 nM 5.17
CHEMBL3900440 Kd = 6700.0 nM 5.17
CHEMBL54151 Kd = 7000.0 nM 5.16
CHEMBL2346950 Kd = 7800.0 nM 5.11
CHEMBL3932345 Kd = 8000.0 nM 5.10
CHEMBL3928103 Kd = 8000.0 nM 5.10
CHEMBL2346944 Kd = 8400.0 nM 5.08
CHEMBL3982697 Kd = 8400.0 nM 5.08
CHEMBL105167 Kd = 8800.0 nM 5.06
CHEMBL105616 Kd = 9200.0 nM 5.04
CHEMBL2346942 Kd = 11000.0 nM 4.96
CHEMBL2346945 Kd = 11000.0 nM 4.96
CHEMBL3960464 Kd = 12000.0 nM 4.92
CHEMBL3969135 Kd = 12000.0 nM 4.92
CHEMBL2346938 Kd = 12000.0 nM 4.92
CHEMBL2346941 Kd = 14000.0 nM 4.85
CHEMBL1976834 Kd = 15000.0 nM 4.82
CHEMBL3944104 Kd = 21000.0 nM 4.68
CHEMBL105099 Kd - -
CHEMBL3975335 Kd - -
CHEMBL2346937 Kd - -
CHEMBL3889940 Kd - -