Assay Detail
Binding
CHEMBL3854595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pseudomonas aeruginosa HemO mutant expressed in Escherichia coli BL21(DE3) assessed as decrease in biliverdin-9alpha-dependent IFP1.4 fluorescence after 16 hrs by spectrophotometric method
26
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 4.47 | 4.95 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2346953 | — | — | 1 | 4.95 |
| CHEMBL3960464 | — | — | 1 | 4.95 |
| CHEMBL2346945 | — | — | 1 | 4.92 |
| CHEMBL2346944 | — | — | 1 | 4.71 |
| CHEMBL3982697 | — | — | 1 | 4.69 |
| CHEMBL3920262 | — | — | 1 | 4.66 |
| CHEMBL3889940 | — | — | 1 | 4.46 |
| CHEMBL3900440 | — | — | 1 | 4.45 |
| CHEMBL1976834 | — | — | 1 | 4.45 |
| CHEMBL2346937 | — | — | 1 | 4.37 |
| CHEMBL3969135 | — | — | 1 | 4.35 |
| CHEMBL2346938 | — | — | 1 | 4.28 |
| CHEMBL3932345 | — | — | 1 | 4.22 |
| CHEMBL104315 | — | — | 1 | 4.19 |
| CHEMBL105099 | — | — | 1 | 4.14 |
| CHEMBL2346941 | — | — | 1 | 4.11 |
| CHEMBL2346950 | — | — | 1 | 4.11 |
| CHEMBL3944104 | — | — | 1 | - |
| CHEMBL3975335 | — | — | 1 | - |
| CHEMBL3928103 | — | — | 1 | - |
| CHEMBL3955732 | — | — | 1 | - |
| CHEMBL105167 | — | — | 2 | - |
| CHEMBL105616 | — | — | 1 | - |
| CHEMBL54151 | — | — | 1 | - |
| CHEMBL2346942 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2346953 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3960464 | — | EC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL2346945 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL2346944 | — | EC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL3982697 | — | EC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL3920262 | — | EC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL3889940 | — | EC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL3900440 | — | EC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL1976834 | — | EC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL2346937 | — | EC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL3969135 | — | EC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL2346938 | — | EC50 | = | 52400.0 | nM | 4.28 |
| CHEMBL3932345 | — | EC50 | = | 60300.0 | nM | 4.22 |
| CHEMBL104315 | — | EC50 | = | 64400.0 | nM | 4.19 |
| CHEMBL105099 | — | EC50 | = | 72700.0 | nM | 4.14 |
| CHEMBL2346950 | — | EC50 | = | 77400.0 | nM | 4.11 |
| CHEMBL2346941 | — | EC50 | = | 77500.0 | nM | 4.11 |
| CHEMBL105167 | — | Inhibition | - | % | - | |
| CHEMBL3955732 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL3975335 | — | EC50 | - | — | - | |
| CHEMBL3928103 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL105167 | — | EC50 | = | 123000.0 | nM | - |
| CHEMBL3944104 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL105616 | — | EC50 | = | 102000.0 | nM | - |
| CHEMBL54151 | — | EC50 | = | 122000.0 | nM | - |
| CHEMBL2346942 | — | EC50 | > | 200000.0 | nM | - |