Assay Detail
Binding
CHEMBL3854658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of trypsin (unknown origin) using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.76 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3891120 | — | — | 1 | 6.35 |
| CHEMBL3935309 | — | — | 1 | 6.02 |
| CHEMBL3930523 | — | — | 1 | 5.89 |
| CHEMBL3951940 | — | — | 1 | 5.80 |
| CHEMBL3917434 | — | — | 1 | 5.79 |
| CHEMBL3902498 | — | — | 1 | 5.52 |
| CHEMBL3980787 | — | — | 1 | 5.50 |
| CHEMBL3942944 | — | — | 1 | 5.23 |
| CHEMBL3978562 | — | — | 1 | - |
| CHEMBL3926417 | — | — | 1 | - |
| CHEMBL3907376 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3891120 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL3935309 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL3930523 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3951940 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3917434 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL3902498 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL3980787 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL3942944 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL3978562 | — | Ki | > | 6200.0 | nM | - |
| CHEMBL3926417 | — | Ki | > | 6200.0 | nM | - |
| CHEMBL3907376 | — | Ki | > | 10000.0 | nM | - |