Assay Detail
Binding
CHEMBL3855498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of trypsin (unknown origin) at 25 degC by chromogenic substrate assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.66 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3956096 | — | — | 1 | 6.30 |
| CHEMBL3984725 | — | — | 1 | 5.66 |
| CHEMBL3898371 | — | — | 1 | 5.56 |
| CHEMBL3900166 | — | — | 1 | 5.47 |
| CHEMBL3967204 | — | — | 1 | 5.31 |
| CHEMBL3934882 | — | — | 1 | - |
| CHEMBL3895930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3956096 | — | Ki | = | 505.0 | nM | 6.30 |
| CHEMBL3984725 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3898371 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL3900166 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL3967204 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL3934882 | — | Ki | > | 6200.0 | nM | - |
| CHEMBL3895930 | — | Ki | > | 6200.0 | nM | - |