Assay Detail
Functional
CHEMBL3855552
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Antiviral activity against BK polyomavirus Gardner infected in human HFF cells assessed as reduction in DNA copy number after 7 days by PCR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Betapolyomavirus hominis |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.72 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.96 |
| CHEMBL3970659 | — | — | 1 | 5.77 |
| CHEMBL3985514 | — | — | 1 | 5.75 |
| CHEMBL3899482 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3970659 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3985514 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3899482 | — | EC50 | = | 3900.0 | nM | 5.41 |