Assay Detail
Binding
CHEMBL3855896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.15 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3904942 | — | — | 1 | 8.68 |
| CHEMBL1673047 | — | — | 1 | 8.32 |
| CHEMBL3950648 | — | — | 1 | 7.80 |
| CHEMBL3909068 | — | — | 1 | 7.64 |
| CHEMBL3926951 | — | — | 1 | 7.31 |
| CHEMBL3979343 | — | — | 1 | 7.23 |
| CHEMBL3942643 | — | — | 1 | 6.96 |
| CHEMBL3959351 | — | — | 1 | 6.82 |
| CHEMBL3907932 | — | — | 1 | 6.72 |
| CHEMBL3898901 | — | — | 1 | 6.57 |
| CHEMBL3889977 | — | — | 1 | 6.46 |
| CHEMBL3932938 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3904942 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1673047 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3950648 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3909068 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3926951 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3979343 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3942643 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3959351 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3907932 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3898901 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3889977 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3932938 | — | IC50 | = | 4900.0 | nM | 5.31 |