Assay Detail
Binding
CHEMBL3855950
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Displacement of [125I]-p-iodoclonidine from I1 receptor imidazoline binding site in Sprague-Dawley rat kidney cell membranes after 30 mins by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | kidney |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.97 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337862 | — | — | 1 | 8.85 |
| CHEMBL3904276 | — | — | 1 | 8.70 |
| CHEMBL3961335 | — | — | 1 | 8.40 |
| CHEMBL51358 | — | — | 1 | 8.12 |
| CHEMBL3892351 | — | — | 1 | 8.08 |
| CHEMBL1439667 | — | — | 1 | 7.75 |
| CHEMBL3920069 | — | — | 1 | 7.62 |
| CHEMBL3939078 | — | — | 1 | 7.16 |
| CHEMBL3911124 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337862 | — | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL3904276 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL3961335 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL51358 | — | Ki | = | 7.586 | nM | 8.12 |
| CHEMBL3892351 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL1439667 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL3920069 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL3939078 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL3911124 | — | Ki | = | 97.72 | nM | 7.01 |