Assay Detail
Binding
CHEMBL3855951
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-2-BFI from I2 receptor imidazoline binding site in Sprague-Dawley rat brain membranes after 30 mins by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.94 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1439667 | — | — | 1 | 9.11 |
| CHEMBL3920069 | — | — | 1 | 8.79 |
| CHEMBL3939078 | — | — | 1 | 8.30 |
| CHEMBL3911124 | — | — | 1 | 8.08 |
| CHEMBL3904276 | — | — | 1 | 8.06 |
| CHEMBL51358 | — | — | 1 | 7.90 |
| CHEMBL3961335 | — | — | 1 | 7.85 |
| CHEMBL3892351 | — | — | 1 | 7.29 |
| CHEMBL337862 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1439667 | — | Ki | = | 0.7762 | nM | 9.11 |
| CHEMBL3920069 | — | Ki | = | 1.622 | nM | 8.79 |
| CHEMBL3939078 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL3911124 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL3904276 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL51358 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL3961335 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL3892351 | — | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL337862 | — | Ki | = | 794.33 | nM | 6.10 |