Assay Detail
Binding
CHEMBL3856316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIRT1 (unknown origin) using acetylated lysine as substrate by Fluor de Lys assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.35 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561194 | ANILINOBENZAMIDE | — | 1 | 4.77 |
| CHEMBL23832 | FENAMIC ACID | 1.0 | 1 | 4.17 |
| CHEMBL2152587 | — | — | 1 | 4.12 |
| CHEMBL2152586 | — | — | 1 | - |
| CHEMBL3915417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561194 | ANILINOBENZAMIDE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL23832 | FENAMIC ACID | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL2152587 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL2152586 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3915417 | — | IC50 | > | 100000.0 | nM | - |