Assay Detail
Binding
CHEMBL3856337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged SIRT1 overexpressed in Escherichia coli DH5alpha assessed as deacetylation activity using [3H]-MPSDKTIGG as substrate measured after overnight incubation by liquid scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.01 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3956664 | — | — | 1 | 5.16 |
| CHEMBL3828225 | — | — | 1 | 5.05 |
| CHEMBL1237210 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3956664 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3828225 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1237210 | — | IC50 | = | 15000.0 | nM | 4.82 |