Assay Detail
Binding
CHEMBL3856343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.66 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3986181 | — | — | 1 | 6.96 |
| CHEMBL1450796 | — | — | 1 | 6.96 |
| CHEMBL578512 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3986181 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1450796 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL578512 | — | IC50 | = | 870.0 | nM | 6.06 |