Assay Detail

CHEMBL3856544

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Binding

Inhibition of CDK6/cyclin D (unknown origin)

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.

Sonawane YA, Taylor MA, Napoleon JV, Rana S, Contreras JI, Natarajan A.
J Med Chem (2016) 59 : 8667 -8684
PubMed 27171036 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.40	6.40
Ki	1	6.18	6.18

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3969723	—	—	1	6.40
CHEMBL445813	AT-7519	2.0	1	6.18
CHEMBL296468	BMS-387032	1.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3969723	—	IC50	=	396.0	nM	6.40
CHEMBL445813	AT-7519	Ki	=	660.0	nM	6.18
CHEMBL296468	BMS-387032	IC50	>	1000.0	nM	-