Assay Detail

CHEMBL3856552

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Binding

Inhibition of human GST-tagged CDK5

ChEMBL ↗

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Target

Cyclin-dependent kinase 5 (CHEMBL4036) ↗

Open DB target context

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Primary target Cyclin-dependent kinase 5

CHEMBL4036

Anchored from Assay target.

Protein identity Cyclin-dependent kinase 5

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cyclin-dependent kinase 5 (CHEMBL4036) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.

Sonawane YA, Taylor MA, Napoleon JV, Rana S, Contreras JI, Natarajan A.
J Med Chem (2016) 59 : 8667 -8684
PubMed 27171036 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.52	8.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1944698	ZOTIRACICLIB	2.0	1	8.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1944698	ZOTIRACICLIB	IC50	=	3.0	nM	8.52