Assay Detail
Binding
CHEMBL3857090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fluorescien-conjugated coactivator PGC1a binding to ERRbeta (unknown origin) after 1 hr by TR-FRET assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.65 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3961676 | — | — | 1 | 6.14 |
| CHEMBL3978054 | — | — | 1 | 5.16 |
| CHEMBL3957546 | — | — | 1 | - |
| CHEMBL3897416 | — | — | 1 | - |
| CHEMBL3968559 | — | — | 1 | - |
| CHEMBL3932162 | — | — | 1 | - |
| CHEMBL3973526 | — | — | 1 | - |
| CHEMBL3956562 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3961676 | — | IC50 | = | 722.0 | nM | 6.14 |
| CHEMBL3978054 | — | IC50 | = | 6950.0 | nM | 5.16 |
| CHEMBL3957546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3897416 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3968559 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3932162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3973526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3956562 | — | IC50 | > | 10000.0 | nM | - |