Assay Detail
Binding
CHEMBL3857092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AD293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.85 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3961676 | — | — | 1 | 7.32 |
| CHEMBL3897416 | — | — | 1 | 7.24 |
| CHEMBL3932162 | — | — | 1 | 7.11 |
| CHEMBL3957546 | — | — | 1 | 7.10 |
| CHEMBL3956562 | — | — | 1 | 6.96 |
| CHEMBL3968559 | — | — | 1 | 6.73 |
| CHEMBL3973526 | — | — | 1 | 6.17 |
| CHEMBL3978054 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3961676 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3897416 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3932162 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3957546 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3956562 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL3968559 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL3973526 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL3978054 | — | IC50 | = | 719.0 | nM | 6.14 |