Assay Detail
Binding
CHEMBL3857944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKr in guinea pig myocytes by voltage clamp method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.22 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16900 | L-768673 | — | 1 | 5.22 |
| CHEMBL277513 | — | — | 1 | - |
| CHEMBL428691 | — | — | 1 | - |
| CHEMBL277609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16900 | L-768673 | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL277513 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL428691 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL277609 | — | IC50 | > | 1000.0 | nM | - |