Assay Detail
Functional
CHEMBL3857952
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Leishmanicidal activity against promastigote form of Leishmania donovani MHOM/IN/80/DD8 after 48 hrs by resazurin dye-based fluorometric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antileishmanial activity of C7- and C12-functionalized dehydroabietylamine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.70 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.82 |
| CHEMBL3806242 | — | — | 1 | 5.66 |
| CHEMBL3932424 | — | — | 1 | 5.55 |
| CHEMBL3343779 | — | — | 1 | 5.50 |
| CHEMBL3343778 | — | — | 1 | 5.40 |
| CHEMBL3343777 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3806242 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3932424 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3343779 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3343778 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3343777 | — | IC50 | = | 5400.0 | nM | 5.27 |