Assay Detail
Functional
CHEMBL3857955
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Leishmanicidal activity against amastigote form of Leishmania infantum MCAN/ES/96/BCN150 infected in mouse J774 cells after 48 hrs by resazurin dye-based fluorometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antileishmanial activity of C7- and C12-functionalized dehydroabietylamine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.08 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343778 | — | — | 1 | 5.60 |
| CHEMBL3343779 | — | — | 1 | 5.48 |
| CHEMBL3806242 | — | — | 1 | 5.33 |
| CHEMBL3343777 | — | — | 1 | 4.76 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343778 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3343779 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3806242 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3343777 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 58100.0 | nM | 4.24 |