Assay Detail
Binding
CHEMBL3858016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DTG from sigma2 receptor in rat liver membranes after 120 mins by scintillation counting method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.71 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3983403 | — | — | 1 | 7.38 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.27 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL3964384 | — | — | 1 | 7.05 |
| CHEMBL3966143 | — | — | 1 | 7.03 |
| CHEMBL3955644 | — | — | 1 | 6.98 |
| CHEMBL3975617 | — | — | 1 | 6.96 |
| CHEMBL3984272 | — | — | 1 | 6.92 |
| CHEMBL3895475 | — | — | 1 | 6.77 |
| CHEMBL3894565 | — | — | 1 | 6.76 |
| CHEMBL3983612 | — | — | 1 | 6.72 |
| CHEMBL3975268 | — | — | 1 | 6.65 |
| CHEMBL3913418 | — | — | 1 | 6.62 |
| CHEMBL3913581 | — | — | 1 | 6.62 |
| CHEMBL3964306 | — | — | 1 | 6.60 |
| CHEMBL3931495 | — | — | 1 | 6.60 |
| CHEMBL3966773 | — | — | 1 | 6.59 |
| CHEMBL3983252 | — | — | 1 | 6.56 |
| CHEMBL3904413 | — | — | 1 | 6.50 |
| CHEMBL3946295 | — | — | 1 | 6.50 |
| CHEMBL3958562 | — | — | 1 | 6.38 |
| CHEMBL3954990 | — | — | 1 | 6.22 |
| CHEMBL3547159 | — | — | 1 | 6.21 |
| CHEMBL3912537 | — | — | 1 | 5.92 |
| CHEMBL3922582 | — | — | 1 | - |
| CHEMBL3894798 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3983403 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL3964384 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL3966143 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL3955644 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL3975617 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3984272 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL3895475 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL3894565 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL3983612 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL3975268 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL3913418 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL3913581 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL3964306 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL3931495 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL3966773 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL3983252 | — | Ki | = | 274.0 | nM | 6.56 |
| CHEMBL3904413 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL3946295 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL3958562 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL3954990 | — | Ki | = | 603.0 | nM | 6.22 |
| CHEMBL3547159 | — | Ki | = | 621.0 | nM | 6.21 |
| CHEMBL3912537 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3922582 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL3894798 | — | Ki | > | 3000.0 | nM | - |