Assay Detail
Binding
CHEMBL3858190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of circular DNA translation in Escherichia coli S30 extract after 60 mins by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.81 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1747 | TOBRAMYCIN | 4.0 | 1 | 8.21 |
| CHEMBL3960533 | — | — | 1 | 6.89 |
| CHEMBL3955713 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1747 | TOBRAMYCIN | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3960533 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3955713 | — | IC50 | = | 4700.0 | nM | 5.33 |