Assay Detail
Binding
CHEMBL3858191
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Inhibition of Pseudomonas aeruginosa DNA gyrase A assessed as inhibition of DNA supercoiling using PBR322 DNA as substrate after 30 mins by SYBR Gold staining based agarose gel electrophoresis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.28 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3960533 | — | — | 1 | 5.68 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 5.58 |
| CHEMBL3899010 | — | — | 1 | 5.58 |
| CHEMBL3955713 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3960533 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3899010 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3955713 | — | IC50 | = | 54700.0 | nM | 4.26 |