Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3859989

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of renin in human plasma by radioimmunoassay
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Plasma
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Renin (CHEMBL286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.
Imaeda Y, Tokuhara H, Fukase Y, Kanagawa R, Kajimoto Y, Kusumoto K, Kondo M, Snell G, Behnke CA, Kuroita T.
ACS Med Chem Lett (2016) 7 : 933 -938
PubMed 27774132 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 8.63 9.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3907708 2 9.46
CHEMBL3958809 1 9.10
CHEMBL3969876 IMARIKIREN HYDROCHLORIDE 2.0 1 8.68
CHEMBL3916704 1 8.35
CHEMBL3961799 1 8.34
CHEMBL3986466 1 8.28
CHEMBL3959431 1 8.00
CHEMBL3889771 1 -
CHEMBL3978240 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3907708 IC50 = 0.35 nM 9.46
CHEMBL3958809 IC50 = 0.79 nM 9.10
CHEMBL3907708 IC50 = 1.4 nM 8.85
CHEMBL3969876 IMARIKIREN HYDROCHLORIDE IC50 = 2.1 nM 8.68
CHEMBL3916704 IC50 = 4.5 nM 8.35
CHEMBL3961799 IC50 = 4.6 nM 8.34
CHEMBL3986466 IC50 = 5.2 nM 8.28
CHEMBL3959431 IC50 = 10.0 nM 8.00
CHEMBL3889771 IC50 > 10.0 nM -
CHEMBL3978240 IC50 > 10.0 nM -