Assay Detail
Binding
CHEMBL3860118
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Binding affinity to native signal deficient and TEV cleavage site containing His-tagged Klebsiella pneumoniae OXA-48 expressed in Escherichia coli assessed as dissociation constant by SPR assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Klebsiella pneumoniae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 18 | 5.19 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127 | MEROPENEM | 4.0 | 1 | 6.07 |
| CHEMBL3910343 | — | — | 1 | 4.30 |
| CHEMBL3913021 | — | — | 1 | - |
| CHEMBL3896367 | — | — | 1 | - |
| CHEMBL3967375 | — | — | 1 | - |
| CHEMBL1834963 | — | — | 1 | - |
| CHEMBL1327484 | — | — | 1 | - |
| CHEMBL582878 | — | — | 1 | - |
| CHEMBL2018158 | — | — | 1 | - |
| CHEMBL3950623 | — | — | 1 | - |
| CHEMBL107518 | — | — | 1 | - |
| CHEMBL109074 | — | — | 1 | - |
| CHEMBL123234 | — | — | 1 | - |
| CHEMBL3908259 | — | — | 1 | - |
| CHEMBL3931620 | — | — | 1 | - |
| CHEMBL541 | BENZOIC ACID | -1.0 | 1 | - |
| CHEMBL72628 | 2-PICOLINIC ACID | — | 1 | - |
| CHEMBL3951674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127 | MEROPENEM | Kd | = | 850.0 | nM | 6.07 |
| CHEMBL3910343 | — | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL3913021 | — | Kd | = | 280000.0 | nM | - |
| CHEMBL3896367 | — | Kd | = | 280000.0 | nM | - |
| CHEMBL3967375 | — | Kd | = | 310000.0 | nM | - |
| CHEMBL1834963 | — | Kd | - | — | - | |
| CHEMBL1327484 | — | Kd | - | — | - | |
| CHEMBL582878 | — | Kd | = | 430000.0 | nM | - |
| CHEMBL2018158 | — | Kd | = | 1380000.0 | nM | - |
| CHEMBL3950623 | — | Kd | = | 1180000.0 | nM | - |
| CHEMBL107518 | — | Kd | = | 660000.0 | nM | - |
| CHEMBL109074 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL123234 | — | Kd | = | 370000.0 | nM | - |
| CHEMBL3908259 | — | Kd | = | 330000.0 | nM | - |
| CHEMBL3931620 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL541 | BENZOIC ACID | Kd | > | 1000000.0 | nM | - |
| CHEMBL72628 | 2-PICOLINIC ACID | Kd | > | 1000000.0 | nM | - |
| CHEMBL3951674 | — | Kd | = | 700000.0 | nM | - |