Assay Detail
Binding
CHEMBL3860169
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in Escherichia coli BL21 CodonPlus by pyruvate kinase/lactate dehydrogenase-linked assay
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.93 | 5.24 |
| Imax | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171637 | PHYSODIC ACID | — | 2 | 5.24 |
| CHEMBL368810 | — | — | 2 | 4.61 |
| CHEMBL220486 | VARIOLARIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171637 | PHYSODIC ACID | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL368810 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL368810 | — | Imax | = | 90.0 | % | - |
| CHEMBL171637 | PHYSODIC ACID | Imax | = | 90.0 | % | - |
| CHEMBL220486 | VARIOLARIC ACID | IC50 | - | — | - |