Assay Detail
Binding
CHEMBL3860975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PDE5A
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.38 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1520 | VARDENAFIL | 4.0 | 1 | 9.05 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.07 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1520 | VARDENAFIL | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL779 | TADALAFIL | IC50 | = | 9.4 | nM | 8.03 |