Assay Detail
ADMET
CHEMBL3860992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate after 30 mins by fluorescence analysis
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.85 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3923840 | — | — | 1 | 7.05 |
| CHEMBL3970984 | — | — | 1 | 6.93 |
| CHEMBL3979179 | — | — | 1 | 6.78 |
| CHEMBL3895838 | — | — | 1 | 6.47 |
| CHEMBL3986487 | — | — | 1 | 6.47 |
| CHEMBL3936651 | — | — | 1 | 6.37 |
| CHEMBL3907730 | — | — | 1 | 6.31 |
| CHEMBL3900593 | — | — | 1 | 6.31 |
| CHEMBL3978271 | — | — | 1 | 6.15 |
| CHEMBL3955253 | — | — | 1 | 6.14 |
| CHEMBL3982024 | — | — | 1 | 5.91 |
| CHEMBL3925737 | — | — | 1 | 5.88 |
| CHEMBL3984639 | — | — | 1 | 5.73 |
| CHEMBL3901988 | — | — | 1 | 5.73 |
| CHEMBL3982925 | — | — | 1 | 5.73 |
| CHEMBL3954968 | — | — | 1 | 5.71 |
| CHEMBL3962991 | — | — | 1 | 5.69 |
| CHEMBL3974954 | — | — | 1 | 5.65 |
| CHEMBL3926754 | — | — | 1 | 5.33 |
| CHEMBL3914813 | — | — | 1 | 5.19 |
| CHEMBL3899814 | — | — | 1 | 5.16 |
| CHEMBL3945565 | — | — | 1 | 5.01 |
| CHEMBL3944571 | — | — | 1 | 4.86 |
| CHEMBL3962031 | — | — | 1 | 4.85 |
| CHEMBL3969922 | — | — | 1 | 4.76 |
| CHEMBL3940720 | — | — | 1 | - |
| CHEMBL3895860 | — | — | 1 | - |
| CHEMBL3893017 | — | — | 1 | - |
| CHEMBL3973027 | — | — | 1 | - |
| CHEMBL3908767 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3923840 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3970984 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3979179 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL3895838 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL3986487 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL3936651 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL3907730 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3900593 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3978271 | — | IC50 | = | 712.0 | nM | 6.15 |
| CHEMBL3955253 | — | IC50 | = | 729.0 | nM | 6.14 |
| CHEMBL3982024 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL3925737 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL3901988 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL3982925 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL3984639 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL3954968 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL3962991 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL3974954 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL3926754 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL3914813 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL3899814 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL3945565 | — | IC50 | = | 9830.0 | nM | 5.01 |
| CHEMBL3944571 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3962031 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3969922 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL3890386 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3897643 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3898715 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3950140 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3894057 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3954259 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3966438 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3927691 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3955306 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3932796 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3904785 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3955289 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3976546 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3970271 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3898716 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3956031 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3936720 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3908767 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3973027 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3893017 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3895860 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3940720 | — | IC50 | > | 20000.0 | nM | - |