Assay Detail
Binding
CHEMBL3861272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant mTOR using substrate PI incubated for 1 hr by Adapta kinase assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Class II Phosphoinositide 3-Kinases as Novel Drug Targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.57 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.70 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 370.0 | nM | 6.43 |