Assay Detail
Binding
CHEMBL3861345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thermodynamic properties of leukotriene A4 hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.76 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112671 | — | — | 1 | 8.22 |
| CHEMBL3921982 | — | — | 1 | 7.22 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 6.52 |
| CHEMBL3883608 | — | — | 1 | 6.40 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112671 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3921982 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL29292 | UBENIMEX | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3883608 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 3600.0 | nM | 5.44 |