Assay Detail
Binding
CHEMBL3861346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thermodynamic properties of leukotriene A4 hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.29 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3921982 | — | — | 1 | 6.80 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 6.50 |
| CHEMBL3883608 | — | — | 1 | 6.44 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3921982 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL29292 | UBENIMEX | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL3883608 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL1560 | CAPTOPRIL | Ki | = | 3700.0 | nM | 5.43 |