Assay Detail
Binding
CHEMBL3861350
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Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thermodynamic properties of leukotriene A4 hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.10 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3921982 | — | — | 1 | 6.57 |
| CHEMBL112671 | — | — | 1 | 6.54 |
| CHEMBL3883608 | — | — | 1 | 6.51 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 5.69 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3921982 | — | Kd | = | 270.0 | nM | 6.57 |
| CHEMBL112671 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL3883608 | — | Kd | = | 310.0 | nM | 6.51 |
| CHEMBL29292 | UBENIMEX | Kd | = | 2050.0 | nM | 5.69 |
| CHEMBL1560 | CAPTOPRIL | Kd | = | 6250.0 | nM | 5.20 |