Assay Detail
Binding
CHEMBL3861640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.78 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7162 | NS-398 | — | 1 | 8.15 |
| CHEMBL3747473 | — | — | 1 | 7.22 |
| CHEMBL3922351 | — | — | 1 | 6.26 |
| CHEMBL3747171 | — | — | 1 | 6.16 |
| CHEMBL3921251 | — | — | 1 | 6.10 |
| CHEMBL3961576 | — | — | 1 | - |
| CHEMBL3949085 | — | — | 1 | - |
| CHEMBL3928687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7162 | NS-398 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3747473 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3922351 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3747171 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3921251 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3961576 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3949085 | — | IC50 | - | — | - | |
| CHEMBL3928687 | — | IC50 | - | — | - |