Assay Detail
Binding
CHEMBL3861664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to of humanised RAD51 C-terminal ATPase domain (with deletion of L2 loop residues 288 to 314) from Pyrococcus furiosus expressed in Escherichia coli by ITC method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA repair protein RAD51 homolog 1 (CHEMBL2034807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fragment-to-Lead Medicinal Chemistry Publications in 2015.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.57 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3427781 | — | — | 1 | 5.89 |
| CHEMBL55830 | TRYPTOPHAN METHYL ESTER | — | 1 | 3.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3427781 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL55830 | TRYPTOPHAN METHYL ESTER | Kd | = | 570000.0 | nM | 3.24 |