Assay Detail
Binding
CHEMBL3861815
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Inhibition of Mycobacterium tuberculosis H37Rv acetyltransferase Eis assessed as reduction in enzyme-mediated acetylation by measuring CoASH release after 5 mins by DTNB based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.28 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3931964 | — | — | 1 | 9.62 |
| CHEMBL3911185 | — | — | 1 | 7.57 |
| CHEMBL3963272 | — | — | 1 | 7.25 |
| CHEMBL3900481 | — | — | 1 | 7.10 |
| CHEMBL3909504 | — | — | 1 | 7.00 |
| CHEMBL3967657 | — | — | 1 | 6.64 |
| CHEMBL3918442 | — | — | 1 | 6.60 |
| CHEMBL3984204 | — | — | 1 | 6.52 |
| CHEMBL1600985 | — | — | 1 | 6.43 |
| CHEMBL3938063 | — | — | 1 | 6.16 |
| CHEMBL3961587 | — | — | 1 | 5.52 |
| CHEMBL3963651 | — | — | 1 | 5.24 |
| CHEMBL3891456 | — | — | 1 | 5.24 |
| CHEMBL3928430 | — | — | 1 | 5.21 |
| CHEMBL3906981 | — | — | 1 | 5.13 |
| CHEMBL3946317 | — | — | 1 | 4.97 |
| CHEMBL3956582 | — | — | 1 | 4.57 |
| CHEMBL3937447 | — | — | 1 | - |
| CHEMBL3969855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3931964 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL3911185 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3963272 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3900481 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3909504 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3967657 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3918442 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3984204 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1600985 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3938063 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3961587 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3963651 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3891456 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3928430 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3906981 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3946317 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3956582 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3937447 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3969855 | — | IC50 | > | 200000.0 | nM | - |