Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3862220

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human MAOB using kynuramine as substrate assessed as decrease in formation of 4-hydroxyquinoline incubated for 20 mins by fluorescence assay
22
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Medchemcomm (2016) 7 : 1628 -1639
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.25 7.70
Ki 11 5.42 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL972 SELEGILINE 4.0 2 8.05
CHEMBL3950869 2 5.59
CHEMBL3932083 2 5.45
CHEMBL326294 ISATIN 2 5.28
CHEMBL3965645 2 4.82
CHEMBL3916392 2 4.52
CHEMBL3923134 2 4.26
CHEMBL3923040 2 -
CHEMBL3986142 2 -
CHEMBL8706 CLORGILINE 2.0 2 -
CHEMBL1213366 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL972 SELEGILINE Ki = 9.0 nM 8.05
CHEMBL972 SELEGILINE IC50 = 20.0 nM 7.70
CHEMBL3950869 Ki = 2570.0 nM 5.59
CHEMBL3932083 Ki = 3580.0 nM 5.45
CHEMBL326294 ISATIN Ki = 5200.0 nM 5.28
CHEMBL3950869 IC50 = 5960.0 nM 5.22
CHEMBL3932083 IC50 = 8320.0 nM 5.08
CHEMBL326294 ISATIN IC50 = 12070.0 nM 4.92
CHEMBL3965645 Ki = 15150.0 nM 4.82
CHEMBL3916392 Ki = 30380.0 nM 4.52
CHEMBL3965645 IC50 = 35190.0 nM 4.45
CHEMBL3923134 Ki = 55180.0 nM 4.26
CHEMBL3916392 IC50 = 70580.0 nM 4.15
CHEMBL1213366 Ki - -
CHEMBL3923040 IC50 > 100000.0 nM -
CHEMBL8706 CLORGILINE Ki - -
CHEMBL3986142 Ki - -
CHEMBL3923040 Ki - -
CHEMBL1213366 IC50 - -
CHEMBL8706 CLORGILINE IC50 - -
CHEMBL3986142 IC50 > 100000.0 nM -
CHEMBL3923134 IC50 = 128200.0 nM -