Assay Detail
Binding
CHEMBL3862253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant SHP2 (unknown origin) using pNPP as substrate by spectrophotometric method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and evaluation of novel <sup>19</sup>F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.04 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3985776 | — | — | 1 | 5.50 |
| CHEMBL3918902 | — | — | 1 | 5.46 |
| CHEMBL3979554 | — | — | 1 | 5.17 |
| CHEMBL3909342 | — | — | 1 | 5.16 |
| CHEMBL3900333 | — | — | 1 | 5.07 |
| CHEMBL3899171 | — | — | 1 | 5.05 |
| CHEMBL3908861 | — | — | 1 | 4.89 |
| CHEMBL3971448 | — | — | 1 | 4.72 |
| CHEMBL3980114 | — | — | 1 | 4.71 |
| CHEMBL3927816 | — | — | 1 | 4.69 |
| CHEMBL3938397 | — | — | 1 | - |
| CHEMBL3901405 | — | — | 1 | - |
| CHEMBL3929350 | — | — | 1 | - |
| CHEMBL3928298 | — | — | 1 | - |
| CHEMBL3955910 | — | — | 1 | - |
| CHEMBL3911513 | — | — | 1 | - |
| CHEMBL3981501 | — | — | 1 | - |
| CHEMBL3908220 | — | — | 1 | - |
| CHEMBL3936164 | — | — | 1 | - |
| CHEMBL3920938 | — | — | 1 | - |
| CHEMBL3910462 | — | — | 1 | - |
| CHEMBL3968591 | — | — | 1 | - |
| CHEMBL3890830 | — | — | 1 | - |
| CHEMBL3909979 | — | — | 1 | - |
| CHEMBL3890223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3985776 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3918902 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3979554 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3909342 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3900333 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3899171 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3908861 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL3971448 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3980114 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL3927816 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL3938397 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL3901405 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3929350 | — | IC50 | = | 392200.0 | nM | - |
| CHEMBL3928298 | — | IC50 | = | 201800.0 | nM | - |
| CHEMBL3955910 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3911513 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3981501 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3908220 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3936164 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3920938 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3910462 | — | IC50 | = | 114800.0 | nM | - |
| CHEMBL3968591 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3890830 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3909979 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3890223 | — | IC50 | > | 20000.0 | nM | - |