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Assay Detail

CHEMBL3862255

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant CD45 (unknown origin) using pNPP as substrate by spectrophotometric method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Receptor-type tyrosine-protein phosphatase C (CHEMBL3243)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and evaluation of novel <sup>19</sup>F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.
Li Y, Xia G, Guo Q, Wu L, Chen S, Yang Z, Wang W, Zhang ZY, Zhou X, Jiang ZX.
Medchemcomm (2016) 7 : 1672 -1680
PubMed 27529021 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.08 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3985776 1 5.55
CHEMBL3918902 1 5.47
CHEMBL3979554 1 5.28
CHEMBL3909342 1 5.18
CHEMBL3899171 1 5.12
CHEMBL3900333 1 5.11
CHEMBL3908861 1 4.96
CHEMBL3980114 1 4.83
CHEMBL3927816 1 4.79
CHEMBL3909979 1 4.54
CHEMBL3938397 1 -
CHEMBL3901405 1 -
CHEMBL3929350 1 -
CHEMBL3928298 1 -
CHEMBL3955910 1 -
CHEMBL3911513 1 -
CHEMBL3981501 1 -
CHEMBL3908220 1 -
CHEMBL3936164 1 -
CHEMBL3920938 1 -
CHEMBL3910462 1 -
CHEMBL3968591 1 -
CHEMBL3971448 1 -
CHEMBL3890830 1 -
CHEMBL3890223 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3985776 IC50 = 2800.0 nM 5.55
CHEMBL3918902 IC50 = 3400.0 nM 5.47
CHEMBL3979554 IC50 = 5200.0 nM 5.28
CHEMBL3909342 IC50 = 6600.0 nM 5.18
CHEMBL3899171 IC50 = 7600.0 nM 5.12
CHEMBL3900333 IC50 = 7800.0 nM 5.11
CHEMBL3908861 IC50 = 10900.0 nM 4.96
CHEMBL3980114 IC50 = 14900.0 nM 4.83
CHEMBL3927816 IC50 = 16100.0 nM 4.79
CHEMBL3909979 IC50 = 29100.0 nM 4.54
CHEMBL3938397 IC50 = 157200.0 nM -
CHEMBL3901405 IC50 > 500000.0 nM -
CHEMBL3929350 IC50 > 500000.0 nM -
CHEMBL3928298 IC50 = 207100.0 nM -
CHEMBL3955910 IC50 > 500000.0 nM -
CHEMBL3911513 IC50 > 500000.0 nM -
CHEMBL3981501 IC50 > 20000.0 nM -
CHEMBL3908220 IC50 > 20000.0 nM -
CHEMBL3936164 IC50 > 20000.0 nM -
CHEMBL3920938 IC50 > 20000.0 nM -
CHEMBL3910462 IC50 = 112400.0 nM -
CHEMBL3968591 IC50 > 20000.0 nM -
CHEMBL3971448 IC50 > 20000.0 nM -
CHEMBL3890830 IC50 > 20000.0 nM -
CHEMBL3890223 IC50 > 20000.0 nM -