Assay Detail
Binding
CHEMBL3862263
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Competitive inhibition of baker's yeast alpha-glucosidase using alpha-D-glycopyranoside as substrate after 10 to 30 mins by Lineweaver-Burk plot analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.82 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80254 | — | — | 1 | 6.77 |
| CHEMBL406973 | — | — | 1 | 4.99 |
| CHEMBL3926655 | — | — | 1 | 4.16 |
| CHEMBL3974420 | — | — | 1 | 4.16 |
| CHEMBL3919261 | — | — | 1 | 4.03 |
| CHEMBL3953477 | — | — | 1 | - |
| CHEMBL3910334 | — | — | 1 | - |
| CHEMBL3980439 | — | — | 1 | - |
| CHEMBL3960509 | — | — | 1 | - |
| CHEMBL3942035 | — | — | 1 | - |
| CHEMBL3979715 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80254 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL406973 | — | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL3926655 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL3974420 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL3919261 | — | Ki | = | 93000.0 | nM | 4.03 |
| CHEMBL3953477 | — | Ki | = | 265000.0 | nM | - |
| CHEMBL3910334 | — | Ki | = | 183000.0 | nM | - |
| CHEMBL3980439 | — | Ki | = | 125000.0 | nM | - |
| CHEMBL3960509 | — | Ki | = | 526000.0 | nM | - |
| CHEMBL3942035 | — | Ki | = | 975000.0 | nM | - |
| CHEMBL3979715 | — | Ki | = | 358000.0 | nM | - |