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Assay Detail

CHEMBL3862264

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of baker's yeast isomaltase after 10 to 30 mins by Lineweaver-Burk plot analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.
Mena-Barragán T, García-Moreno MI, Nanba E, Higaki K, Concia AL, Clapés P, García Fernández JM, Ortiz Mellet C.
Eur J Med Chem (2016) 121 : 880 -891
PubMed 26361824 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 4.79 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL406973 1 6.40
CHEMBL80254 1 5.23
CHEMBL3919261 1 4.89
CHEMBL3974420 1 4.80
CHEMBL3926655 1 4.72
CHEMBL3953477 1 4.52
CHEMBL3910334 1 4.30
CHEMBL456583 1 4.16
CHEMBL3980439 1 4.05
CHEMBL3979715 1 -
CHEMBL3950752 1 -
CHEMBL3971616 1 -
CHEMBL3942035 1 -
CHEMBL3960509 1 -
CHEMBL3933048 1 -
CHEMBL3970376 1 -
CHEMBL3899927 1 -
CHEMBL3940374 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL406973 Ki = 400.0 nM 6.40
CHEMBL80254 Ki = 5900.0 nM 5.23
CHEMBL3919261 Ki = 13000.0 nM 4.89
CHEMBL3974420 Ki = 16000.0 nM 4.80
CHEMBL3926655 Ki = 19000.0 nM 4.72
CHEMBL3953477 Ki = 30000.0 nM 4.52
CHEMBL3910334 Ki = 50000.0 nM 4.30
CHEMBL456583 Ki = 70000.0 nM 4.16
CHEMBL3980439 Ki = 89000.0 nM 4.05
CHEMBL3979715 Ki = 116000.0 nM -
CHEMBL3950752 Ki = 226000.0 nM -
CHEMBL3971616 Ki = 235000.0 nM -
CHEMBL3942035 Ki = 239000.0 nM -
CHEMBL3960509 Ki = 431000.0 nM -
CHEMBL3933048 Ki = 200000.0 nM -
CHEMBL3970376 Ki = 429000.0 nM -
CHEMBL3899927 Ki = 280000.0 nM -
CHEMBL3940374 Ki = 440000.0 nM -