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Assay Detail

CHEMBL3862265

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of Aspergillus niger amyloglucosidase after 10 to 30 mins by Lineweaver-Burk plot analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Aspergillus niger
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.
Mena-Barragán T, García-Moreno MI, Nanba E, Higaki K, Concia AL, Clapés P, García Fernández JM, Ortiz Mellet C.
Eur J Med Chem (2016) 121 : 880 -891
PubMed 26361824 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 4.60 5.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL80254 1 5.36
CHEMBL456583 1 5.32
CHEMBL3958252 1 4.60
CHEMBL406973 1 4.40
CHEMBL3979715 1 4.27
CHEMBL3910926 1 4.25
CHEMBL3970376 1 4.03
CHEMBL3931823 1 -
CHEMBL3926655 1 -
CHEMBL3953477 1 -
CHEMBL3919261 1 -
CHEMBL3910334 1 -
CHEMBL3980439 1 -
CHEMBL3974420 1 -
CHEMBL3971616 1 -
CHEMBL3950752 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL80254 Ki = 4400.0 nM 5.36
CHEMBL456583 Ki = 4800.0 nM 5.32
CHEMBL3958252 Ki = 25000.0 nM 4.60
CHEMBL406973 Ki = 40000.0 nM 4.40
CHEMBL3979715 Ki = 54000.0 nM 4.27
CHEMBL3910926 Ki = 56000.0 nM 4.25
CHEMBL3970376 Ki = 93000.0 nM 4.03
CHEMBL3931823 Ki = 227000.0 nM -
CHEMBL3926655 Ki = 116000.0 nM -
CHEMBL3953477 Ki = 304000.0 nM -
CHEMBL3919261 Ki = 202000.0 nM -
CHEMBL3910334 Ki = 419000.0 nM -
CHEMBL3980439 Ki = 244000.0 nM -
CHEMBL3974420 Ki = 433000.0 nM -
CHEMBL3971616 Ki = 236000.0 nM -
CHEMBL3950752 Ki = 120000.0 nM -