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Assay Detail

CHEMBL3862267

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of almond beta-glucosidase using beta-D-glycopyranoside as substrate after 10 to 30 mins by Lineweaver-Burk plot analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Prunus dulcis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.
Mena-Barragán T, García-Moreno MI, Nanba E, Higaki K, Concia AL, Clapés P, García Fernández JM, Ortiz Mellet C.
Eur J Med Chem (2016) 121 : 880 -891
PubMed 26361824 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 4.88 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3971616 1 5.72
CHEMBL3974420 1 5.52
CHEMBL3980439 1 5.51
CHEMBL3950752 1 5.44
CHEMBL3910334 1 5.19
CHEMBL3940374 1 4.85
CHEMBL3926655 1 4.60
CHEMBL3937138 1 4.58
CHEMBL406973 1 4.50
CHEMBL80254 1 4.46
CHEMBL3944991 1 4.12
CHEMBL3979715 1 4.02
CHEMBL3899927 1 -
CHEMBL3919261 1 -
CHEMBL3953477 1 -
CHEMBL3909220 1 -
CHEMBL3933048 1 -
CHEMBL3960509 1 -
CHEMBL3958252 1 -
CHEMBL3931823 1 -
CHEMBL3970376 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3971616 Ki = 1900.0 nM 5.72
CHEMBL3974420 Ki = 3000.0 nM 5.52
CHEMBL3980439 Ki = 3100.0 nM 5.51
CHEMBL3950752 Ki = 3600.0 nM 5.44
CHEMBL3910334 Ki = 6500.0 nM 5.19
CHEMBL3940374 Ki = 14000.0 nM 4.85
CHEMBL3926655 Ki = 25000.0 nM 4.60
CHEMBL3937138 Ki = 26000.0 nM 4.58
CHEMBL406973 Ki = 32000.0 nM 4.50
CHEMBL80254 Ki = 35000.0 nM 4.46
CHEMBL3944991 Ki = 76000.0 nM 4.12
CHEMBL3979715 Ki = 96000.0 nM 4.02
CHEMBL3899927 Ki = 144000.0 nM -
CHEMBL3919261 Ki = 277000.0 nM -
CHEMBL3953477 Ki = 105000.0 nM -
CHEMBL3909220 Ki = 435000.0 nM -
CHEMBL3933048 Ki = 172000.0 nM -
CHEMBL3960509 Ki = 353000.0 nM -
CHEMBL3958252 Ki = 437000.0 nM -
CHEMBL3931823 Ki = 575000.0 nM -
CHEMBL3970376 Ki = 149000.0 nM -