Assay Detail
Binding
CHEMBL3862279
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Inhibition of human beta-glucocerebrosidase using 4-methylumbelliferyl beta-D glycopyranoside as substrate at pH 5 by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.21 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3979715 | — | — | 1 | 4.40 |
| CHEMBL3974420 | — | — | 1 | 4.26 |
| CHEMBL3909220 | — | — | 1 | 4.25 |
| CHEMBL3980439 | — | — | 1 | 4.12 |
| CHEMBL3950752 | — | — | 1 | 4.04 |
| CHEMBL3931823 | — | — | 1 | - |
| CHEMBL3937138 | — | — | 1 | - |
| CHEMBL3953477 | — | — | 1 | - |
| CHEMBL3933048 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3979715 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3974420 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3909220 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL3980439 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL3950752 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL3931823 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3937138 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL3953477 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3933048 | — | IC50 | = | 645000.0 | nM | - |