Assay Detail
Binding
CHEMBL3862299
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Inhibition of human recombinant MAOA using p-tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by horse-radish peroxidase/amplex red-based fluorometric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.06 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 7.80 |
| CHEMBL3910142 | — | — | 1 | 5.21 |
| CHEMBL3291019 | — | — | 1 | 5.17 |
| CHEMBL3901082 | — | — | 1 | 4.99 |
| CHEMBL3972214 | — | — | 1 | 4.91 |
| CHEMBL3892118 | — | — | 1 | 4.45 |
| CHEMBL3961103 | — | — | 1 | 4.43 |
| CHEMBL3931599 | — | — | 1 | 4.33 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.26 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3910142 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3291019 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3901082 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL3972214 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3892118 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL3961103 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3931599 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL972 | SELEGILINE | IC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL502 | DONEPEZIL | IC50 | > | 1000000.0 | nM | - |