Assay Detail
Binding
CHEMBL3862353
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Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for second binding site of TTR by isothermal titration calorimetric method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.52 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 6.56 |
| CHEMBL3890392 | — | — | 1 | 6.56 |
| CHEMBL3959466 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | Kd | = | 274.0 | nM | 6.56 |
| CHEMBL3890392 | — | Kd | = | 278.0 | nM | 6.56 |
| CHEMBL3959466 | — | Kd | = | 357.0 | nM | 6.45 |