Assay Detail
Binding
CHEMBL3862758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to DPP4 (unknown origin) assessed as dissociation constant by SPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.26 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3941804 | — | — | 1 | 8.62 |
| CHEMBL2105762 | OMARIGLIPTIN | 4.0 | 1 | 8.56 |
| CHEMBL3944427 | — | — | 1 | 7.96 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3941804 | — | Kd | = | 2.38 | nM | 8.62 |
| CHEMBL2105762 | OMARIGLIPTIN | Kd | = | 2.75 | nM | 8.56 |
| CHEMBL3944427 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL1422 | SITAGLIPTIN | Kd | = | 12.7 | nM | 7.90 |