Assay Detail
Binding
CHEMBL3862958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase activity in human M14 cells using biotin-labeled TeloTAGGG as primer preincubated for 48 hrs followed by primer addition measured after 30 mins by PCR-ELISA
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | M14 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| IC50 | 1 | 7.90 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3948172 | — | — | 2 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3948172 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL3948172 | — | Inhibition | - | % | - |