Assay Detail
Binding
CHEMBL3863078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain PKC assessed as reduction in phosphatidyl serine/Ca2+-stimulated calf thymus histone H1 phosphorylation after 3 mins in presence of [gamma32P]ATP by liquid scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.82 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68236 | — | — | 1 | 5.52 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68236 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 75000.0 | nM | 4.12 |