Assay Detail
Binding
CHEMBL3863230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by scintillation proximity assay
86
Total Activities
86
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
CDGSH iron-sulfur domain-containing protein 1 (CHEMBL1795168) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of small molecules that bind to the mitochondrial protein mitoNEET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 86 | 5.31 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3979616 | — | — | 1 | 6.83 |
| CHEMBL3893332 | — | — | 1 | 6.29 |
| CHEMBL3970270 | — | — | 1 | 6.16 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.14 |
| CHEMBL230515 | — | — | 1 | 6.11 |
| CHEMBL3890124 | — | — | 1 | 6.08 |
| CHEMBL496587 | — | — | 1 | 6.07 |
| CHEMBL3948168 | — | — | 1 | 6.04 |
| CHEMBL3959175 | — | — | 1 | 6.02 |
| CHEMBL2348829 | — | — | 1 | 5.97 |
| CHEMBL3909388 | — | — | 1 | 5.91 |
| CHEMBL3924991 | — | — | 1 | 5.85 |
| CHEMBL255822 | — | — | 1 | 5.76 |
| CHEMBL2218926 | — | — | 1 | 5.75 |
| CHEMBL305695 | — | — | 1 | 5.74 |
| CHEMBL2018126 | — | — | 1 | 5.71 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.63 |
| CHEMBL3956710 | — | — | 1 | 5.53 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 5.51 |
| CHEMBL224467 | — | — | 1 | 5.50 |
| CHEMBL3976274 | — | — | 1 | 5.49 |
| CHEMBL3891346 | — | — | 1 | 5.48 |
| CHEMBL3982310 | — | — | 1 | 5.48 |
| CHEMBL3967845 | — | — | 1 | 5.48 |
| CHEMBL289159 | TRYPROSTATIN A | — | 1 | 5.47 |
| CHEMBL1208633 | — | — | 1 | 5.47 |
| CHEMBL3945250 | — | — | 1 | 5.46 |
| CHEMBL3927255 | — | — | 1 | 5.41 |
| CHEMBL3930279 | — | — | 1 | 5.35 |
| CHEMBL380899 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3979616 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3893332 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL3970270 | — | IC50 | = | 686.1 | nM | 6.16 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL230515 | — | IC50 | = | 770.1 | nM | 6.11 |
| CHEMBL3890124 | — | IC50 | = | 838.9 | nM | 6.08 |
| CHEMBL496587 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3948168 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3959175 | — | IC50 | = | 945.4 | nM | 6.02 |
| CHEMBL2348829 | — | IC50 | = | 1067.0 | nM | 5.97 |
| CHEMBL3909388 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL3924991 | — | IC50 | = | 1399.0 | nM | 5.85 |
| CHEMBL255822 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL2218926 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL305695 | — | IC50 | = | 1829.0 | nM | 5.74 |
| CHEMBL2018126 | — | IC50 | = | 1964.0 | nM | 5.71 |
| CHEMBL140 | CURCUMIN | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL3956710 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL224467 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL3976274 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL3891346 | — | IC50 | = | 3307.0 | nM | 5.48 |
| CHEMBL3982310 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3967845 | — | IC50 | = | 3289.0 | nM | 5.48 |
| CHEMBL1208633 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL289159 | TRYPROSTATIN A | IC50 | = | 3387.0 | nM | 5.47 |
| CHEMBL3945250 | — | IC50 | = | 3454.0 | nM | 5.46 |
| CHEMBL3927255 | — | IC50 | = | 3858.0 | nM | 5.41 |
| CHEMBL3930279 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL380899 | — | IC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL1823804 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL3938874 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL183906 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL602048 | — | IC50 | = | 7360.0 | nM | 5.13 |
| CHEMBL3917957 | — | IC50 | = | 7983.0 | nM | 5.10 |
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL231616 | TRIAPINE | IC50 | = | 9078.0 | nM | 5.04 |
| CHEMBL1823802 | — | IC50 | = | 9560.0 | nM | 5.02 |
| CHEMBL3967264 | — | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL3936343 | — | IC50 | = | 9657.0 | nM | 5.01 |
| CHEMBL3929569 | — | IC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL1823803 | — | IC50 | = | 13340.0 | nM | 4.88 |
| CHEMBL3901608 | — | IC50 | = | 13650.0 | nM | 4.87 |
| CHEMBL1061 | GLITAZONE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL500110 | — | IC50 | = | 15120.0 | nM | 4.82 |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL3928502 | — | IC50 | = | 19440.0 | nM | 4.71 |
| CHEMBL3911800 | — | IC50 | = | 22270.0 | nM | 4.65 |
| CHEMBL1551 | URSODIOL | IC50 | = | 26540.0 | nM | 4.58 |
| CHEMBL224214 | CARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONE | IC50 | = | 35040.0 | nM | 4.46 |