Assay Detail
Binding
CHEMBL3863231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis
86
Total Activities
86
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
CDGSH iron-sulfur domain-containing protein 1 (CHEMBL1795168) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of small molecules that bind to the mitochondrial protein mitoNEET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 86 | 6.62 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3979616 | — | — | 1 | 8.22 |
| CHEMBL3893332 | — | — | 1 | 7.66 |
| CHEMBL3970270 | — | — | 1 | 7.54 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 7.51 |
| CHEMBL230515 | — | — | 1 | 7.48 |
| CHEMBL3890124 | — | — | 1 | 7.44 |
| CHEMBL496587 | — | — | 1 | 7.43 |
| CHEMBL3948168 | — | — | 1 | 7.41 |
| CHEMBL3959175 | — | — | 1 | 7.40 |
| CHEMBL2348829 | — | — | 1 | 7.34 |
| CHEMBL3909388 | — | — | 1 | 7.28 |
| CHEMBL3924991 | — | — | 1 | 7.22 |
| CHEMBL255822 | — | — | 1 | 7.13 |
| CHEMBL305695 | — | — | 1 | 7.11 |
| CHEMBL2218926 | — | — | 1 | 7.11 |
| CHEMBL2018126 | — | — | 1 | 7.08 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 7.00 |
| CHEMBL3956710 | — | — | 1 | 6.90 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 6.88 |
| CHEMBL224467 | — | — | 1 | 6.87 |
| CHEMBL3976274 | — | — | 1 | 6.86 |
| CHEMBL3982310 | — | — | 1 | 6.85 |
| CHEMBL3891346 | — | — | 1 | 6.85 |
| CHEMBL3967845 | — | — | 1 | 6.85 |
| CHEMBL1208633 | — | — | 1 | 6.84 |
| CHEMBL289159 | TRYPROSTATIN A | — | 1 | 6.84 |
| CHEMBL3945250 | — | — | 1 | 6.83 |
| CHEMBL3927255 | — | — | 1 | 6.78 |
| CHEMBL3930279 | — | — | 1 | 6.72 |
| CHEMBL380899 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3979616 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3893332 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3970270 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL121 | ROSIGLITAZONE | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL230515 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3890124 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL496587 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3948168 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL3959175 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL2348829 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL3909388 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL3924991 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL255822 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL305695 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL2218926 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL2018126 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL140 | CURCUMIN | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL3956710 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL150 | KAEMPFEROL | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL224467 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL3976274 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL3982310 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL3891346 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL3967845 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL289159 | TRYPROSTATIN A | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL1208633 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL3945250 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL3927255 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL3930279 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL380899 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL1823804 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL3938874 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL183906 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL602048 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL3917957 | — | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL595 | PIOGLITAZONE | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL231616 | TRIAPINE | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL1823802 | — | Ki | = | 409.0 | nM | 6.39 |
| CHEMBL3936343 | — | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL3967264 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL3929569 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL1823803 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL3901608 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL1061 | GLITAZONE | Ki | = | 598.0 | nM | 6.22 |
| CHEMBL500110 | — | Ki | = | 646.0 | nM | 6.19 |
| CHEMBL572 | NITROFURANTOIN | Ki | = | 816.0 | nM | 6.09 |
| CHEMBL3928502 | — | Ki | = | 831.0 | nM | 6.08 |
| CHEMBL3911800 | — | Ki | = | 952.0 | nM | 6.02 |
| CHEMBL1551 | URSODIOL | Ki | = | 1134.0 | nM | 5.95 |
| CHEMBL224214 | CARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONE | Ki | = | 1497.0 | nM | 5.83 |