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Assay Detail

CHEMBL3863357

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human MAO-B using p-tyramine as substrate assessed as decrease in H2O2 production incubated for 15 mins by fluorimetric method
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.
Wang Z, Wu J, Yang X, Cai P, Liu Q, Wang KDG, Kong L, Wang X.
Bioorg Med Chem (2016) 24 : 5929 -5940
PubMed 27692996 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 7.64 8.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325761 1 8.37
CHEMBL108697 1 8.30
CHEMBL274030 1 8.19
CHEMBL3938837 1 8.19
CHEMBL3288295 1 8.14
CHEMBL887 RASAGILINE 4.0 1 8.10
CHEMBL2430707 1 8.09
CHEMBL3929816 1 8.08
CHEMBL3771110 1 7.98
CHEMBL1682819 1 7.91
CHEMBL3288293 1 7.90
CHEMBL3741461 1 7.89
CHEMBL3919232 1 7.88
CHEMBL3910900 1 7.86
CHEMBL2430706 1 7.85
CHEMBL1945157 1 7.81
CHEMBL3770015 1 7.81
CHEMBL1945153 1 7.60
CHEMBL3911291 1 7.60
CHEMBL3771258 1 7.60
CHEMBL3770875 1 7.56
CHEMBL3948027 1 7.55
CHEMBL3739471 1 7.41
CHEMBL3741418 1 7.38
CHEMBL3920226 1 7.38
CHEMBL3939253 1 7.37
CHEMBL3892863 1 7.36
CHEMBL3891155 1 7.28
CHEMBL3930258 1 7.25
CHEMBL3927065 1 7.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325761 IC50 = 4.25 nM 8.37
CHEMBL108697 IC50 = 5.03 nM 8.30
CHEMBL274030 IC50 = 6.48 nM 8.19
CHEMBL3938837 IC50 = 6.41 nM 8.19
CHEMBL3288295 IC50 = 7.21 nM 8.14
CHEMBL887 RASAGILINE IC50 = 7.87 nM 8.10
CHEMBL2430707 IC50 = 8.17 nM 8.09
CHEMBL3929816 IC50 = 8.35 nM 8.08
CHEMBL3771110 IC50 = 10.52 nM 7.98
CHEMBL1682819 IC50 = 12.34 nM 7.91
CHEMBL3288293 IC50 = 12.55 nM 7.90
CHEMBL3741461 IC50 = 12.85 nM 7.89
CHEMBL3919232 IC50 = 13.25 nM 7.88
CHEMBL3910900 IC50 = 13.87 nM 7.86
CHEMBL2430706 IC50 = 14.27 nM 7.85
CHEMBL3770015 IC50 = 15.48 nM 7.81
CHEMBL1945157 IC50 = 15.62 nM 7.81
CHEMBL1945153 IC50 = 25.31 nM 7.60
CHEMBL3911291 IC50 = 25.12 nM 7.60
CHEMBL3771258 IC50 = 25.32 nM 7.60
CHEMBL3770875 IC50 = 27.82 nM 7.56
CHEMBL3948027 IC50 = 28.42 nM 7.55
CHEMBL3739471 IC50 = 39.21 nM 7.41
CHEMBL3920226 IC50 = 41.38 nM 7.38
CHEMBL3741418 IC50 = 42.05 nM 7.38
CHEMBL3939253 IC50 = 42.75 nM 7.37
CHEMBL3892863 IC50 = 43.42 nM 7.36
CHEMBL3891155 IC50 = 52.93 nM 7.28
CHEMBL3930258 IC50 = 56.89 nM 7.25
CHEMBL3927065 IC50 = 63.22 nM 7.20
CHEMBL3770333 IC50 = 92.41 nM 7.03
CHEMBL3902282 IC50 = 96.51 nM 7.01
CHEMBL92401 IPRONIAZID IC50 = 8960.0 nM 5.05